Initialising Simcyp
wksz = D:\Users\james.craig\VBE\PP3\simcyp_vbe_output_03\PP3M 350mg.wksz
V24 is supported
Simcyp R package 24.0.18
making new Engine24 object
Looking for interface named Simcyp.Engine.24
Searching CLSID from registered name
Succeeded in QueryInterface
Simcyp System path set to: C:/Program Files/Simcyp Simulator V24/Screens/SystemFiles
Finished Initialisation
Back in R
Initialised Simcyp Major Version: 24
Initialisation ended
---------------------------------------------------------------------------
Workspace: D:\Users\james.craig\VBE\PP3\simcyp_vbe_output_03\PP3M 350mg.wksz

Substrate: Paliperidone Palmitate
Absorption model: First order
Distribution model: Minimal PBPK Model
Elimination: Enzyme kinetics
Route of administration: Custom
Dose 1 - 545.670000
Dose 2 - 545.670000
Dose 3 - 545.670000
Dose 4 - 545.670000
Dose 5 - 545.670000
Dose 6 - 545.670000
Dose scaling: mg
Dose Interval: 2016.000000
Dose Type: Multiple dose
Number of Doses: 6.000000

Substrate Primary Metabolite: Paliperidone 
Absorption model: First order
Distribution model: Full PBPK Model
Elimination: In vivo clearance

Population: Healthy Volunteers
Age Min: 18.000000
Age Max: 65.000000
Proportion of females: 0.500000

Study duration: 10920.000000
Population Type: Virtual population
Number Population: 2500
Number Group: 2500
Number Group Members: 1
---------------------------------------------------------------------------
SetWorkspace Succeeded
[1] TRUE
---------------------
Setting parameter values
Setting parameter value for idLogNormalRadiusMean
/Workspace/Compounds/0/LAISuspensionFormulations/0/ParticleSolidState/idLogNormalRadiusMean=2
Setting number of subjects to 1
Running simulation...
Simulation started
wait for simulation
Simulation Complete
Out of WaitForSimulation
Detaching event handler from source

Simulation complete!
Importing concentration data from DB using:
CompoundID = Substrate
deleting pEngine
releasing pUnknown
Closing Handles
Cleared
Initialising Simcyp
wksz = D:\Users\james.craig\VBE\PP3\simcyp_vbe_output_03\PP3M 350mg.wksz
V24 is supported
Simcyp R package 24.0.18
making new Engine24 object
Looking for interface named Simcyp.Engine.24
Searching CLSID from registered name
Succeeded in QueryInterface
Simcyp System path set to: C:/Program Files/Simcyp Simulator V24/Screens/SystemFiles
Finished Initialisation
Back in R
Initialised Simcyp Major Version: 24
Initialisation ended
---------------------------------------------------------------------------
Workspace: D:\Users\james.craig\VBE\PP3\simcyp_vbe_output_03\PP3M 350mg.wksz

Substrate: Paliperidone Palmitate
Absorption model: First order
Distribution model: Minimal PBPK Model
Elimination: Enzyme kinetics
Route of administration: Custom
Dose 1 - 545.670000
Dose 2 - 545.670000
Dose 3 - 545.670000
Dose 4 - 545.670000
Dose 5 - 545.670000
Dose 6 - 545.670000
Dose scaling: mg
Dose Interval: 2016.000000
Dose Type: Multiple dose
Number of Doses: 6.000000

Substrate Primary Metabolite: Paliperidone 
Absorption model: First order
Distribution model: Full PBPK Model
Elimination: In vivo clearance

Population: Healthy Volunteers
Age Min: 18.000000
Age Max: 65.000000
Proportion of females: 0.500000

Study duration: 10920.000000
Population Type: Virtual population
Number Population: 2500
Number Group: 2500
Number Group Members: 1
---------------------------------------------------------------------------
SetWorkspace Succeeded
[1] TRUE
---------------------
Setting parameter values
Setting parameter value for idLogNormalRadiusMean
/Workspace/Compounds/0/LAISuspensionFormulations/0/ParticleSolidState/idLogNormalRadiusMean=2
Setting number of subjects to 1
Running simulation...
Simulation started
wait for simulation
Simulation Complete
Out of WaitForSimulation
Detaching event handler from source

Simulation complete!
Importing concentration data from DB using:
CompoundID = Substrate
deleting pEngine
releasing pUnknown
Closing Handles
Cleared
Initialising Simcyp
wksz = D:\Users\james.craig\VBE\PP3\simcyp_vbe_output_03\PP3M 350mg.wksz
V24 is supported
Simcyp R package 24.0.18
making new Engine24 object
Looking for interface named Simcyp.Engine.24
Searching CLSID from registered name
Succeeded in QueryInterface
Simcyp System path set to: C:/Program Files/Simcyp Simulator V24/Screens/SystemFiles
Finished Initialisation
Back in R
Initialised Simcyp Major Version: 24
Initialisation ended
---------------------------------------------------------------------------
Workspace: D:\Users\james.craig\VBE\PP3\simcyp_vbe_output_03\PP3M 350mg.wksz

Substrate: Paliperidone Palmitate
Absorption model: First order
Distribution model: Minimal PBPK Model
Elimination: Enzyme kinetics
Route of administration: Custom
Dose 1 - 545.670000
Dose 2 - 545.670000
Dose 3 - 545.670000
Dose 4 - 545.670000
Dose 5 - 545.670000
Dose 6 - 545.670000
Dose scaling: mg
Dose Interval: 2016.000000
Dose Type: Multiple dose
Number of Doses: 6.000000

Substrate Primary Metabolite: Paliperidone 
Absorption model: First order
Distribution model: Full PBPK Model
Elimination: In vivo clearance

Population: Healthy Volunteers
Age Min: 18.000000
Age Max: 65.000000
Proportion of females: 0.500000

Study duration: 10920.000000
Population Type: Virtual population
Number Population: 2500
Number Group: 2500
Number Group Members: 1
---------------------------------------------------------------------------
SetWorkspace Succeeded
[1] TRUE
---------------------
Setting parameter values
Setting parameter value for idLogNormalRadiusMean
/Workspace/Compounds/0/LAISuspensionFormulations/0/ParticleSolidState/idLogNormalRadiusMean=2
Setting number of subjects to 1
Running simulation...
Simulation started
wait for simulation
Simulation Complete
Out of WaitForSimulation
Detaching event handler from source

Simulation complete!
Importing concentration data from DB using:
CompoundID = Substrate
deleting pEngine
releasing pUnknown
Closing Handles
Cleared
Initialising Simcyp
wksz = D:\Users\james.craig\VBE\PP3\simcyp_vbe_output_03\PP3M 350mg.wksz
V24 is supported
Simcyp R package 24.0.18
making new Engine24 object
Looking for interface named Simcyp.Engine.24
Searching CLSID from registered name
Succeeded in QueryInterface
Simcyp System path set to: C:/Program Files/Simcyp Simulator V24/Screens/SystemFiles
Finished Initialisation
Back in R
Initialised Simcyp Major Version: 24
Initialisation ended
---------------------------------------------------------------------------
Workspace: D:\Users\james.craig\VBE\PP3\simcyp_vbe_output_03\PP3M 350mg.wksz

Substrate: Paliperidone Palmitate
Absorption model: First order
Distribution model: Minimal PBPK Model
Elimination: Enzyme kinetics
Route of administration: Custom
Dose 1 - 545.670000
Dose 2 - 545.670000
Dose 3 - 545.670000
Dose 4 - 545.670000
Dose 5 - 545.670000
Dose 6 - 545.670000
Dose scaling: mg
Dose Interval: 2016.000000
Dose Type: Multiple dose
Number of Doses: 6.000000

Substrate Primary Metabolite: Paliperidone 
Absorption model: First order
Distribution model: Full PBPK Model
Elimination: In vivo clearance

Population: Healthy Volunteers
Age Min: 18.000000
Age Max: 65.000000
Proportion of females: 0.500000

Study duration: 10920.000000
Population Type: Virtual population
Number Population: 2500
Number Group: 2500
Number Group Members: 1
---------------------------------------------------------------------------
SetWorkspace Succeeded
[1] TRUE
---------------------
Setting parameter values
Setting parameter value for idLogNormalRadiusMean
/Workspace/Compounds/0/LAISuspensionFormulations/0/ParticleSolidState/idLogNormalRadiusMean=2
Setting number of subjects to 1
Running simulation...
Simulation started
wait for simulation
Simulation Complete
Out of WaitForSimulation
Detaching event handler from source

Simulation complete!
Importing concentration data from DB using:
CompoundID = Substrate
deleting pEngine
releasing pUnknown
Closing Handles
Cleared
Initialising Simcyp
wksz = D:\Users\james.craig\VBE\PP3\simcyp_vbe_output_03\PP3M 350mg.wksz
V24 is supported
Simcyp R package 24.0.18
making new Engine24 object
Looking for interface named Simcyp.Engine.24
Searching CLSID from registered name
Succeeded in QueryInterface
Simcyp System path set to: C:/Program Files/Simcyp Simulator V24/Screens/SystemFiles
Finished Initialisation
Back in R
Initialised Simcyp Major Version: 24
Initialisation ended
---------------------------------------------------------------------------
Workspace: D:\Users\james.craig\VBE\PP3\simcyp_vbe_output_03\PP3M 350mg.wksz

Substrate: Paliperidone Palmitate
Absorption model: First order
Distribution model: Minimal PBPK Model
Elimination: Enzyme kinetics
Route of administration: Custom
Dose 1 - 545.670000
Dose 2 - 545.670000
Dose 3 - 545.670000
Dose 4 - 545.670000
Dose 5 - 545.670000
Dose 6 - 545.670000
Dose scaling: mg
Dose Interval: 2016.000000
Dose Type: Multiple dose
Number of Doses: 6.000000

Substrate Primary Metabolite: Paliperidone 
Absorption model: First order
Distribution model: Full PBPK Model
Elimination: In vivo clearance

Population: Healthy Volunteers
Age Min: 18.000000
Age Max: 65.000000
Proportion of females: 0.500000

Study duration: 10920.000000
Population Type: Virtual population
Number Population: 2500
Number Group: 2500
Number Group Members: 1
---------------------------------------------------------------------------
SetWorkspace Succeeded
[1] TRUE
---------------------
Setting parameter values
Setting parameter value for idLogNormalRadiusMean
/Workspace/Compounds/0/LAISuspensionFormulations/0/ParticleSolidState/idLogNormalRadiusMean=2
Setting number of subjects to 1
Running simulation...
Simulation started
wait for simulation
Simulation Complete
Out of WaitForSimulation
Detaching event handler from source

Simulation complete!
Importing concentration data from DB using:
CompoundID = Substrate
deleting pEngine
releasing pUnknown
Closing Handles
Cleared
Error in unserialize(node$con) : 
  MultisessionFuture (<none>) failed to receive message results from cluster RichSOCKnode #8 (PID 13500 on localhost 'localhost'). The reason reported was 'error reading from connection'. Post-mortem diagnostic: No process exists with this PID, i.e. the localhost worker is no longer alive. The total size of the 14 globals exported is 31.13 KiB. The three largest globals are 'ProfileID' (20.93 KiB of class 'list'), 'run_simulation' (6.66 KiB of class 'function') and '...furrr_map_fn' (1.14 KiB of class 'function')
Calls: <Anonymous> ... resolved -> resolved.ClusterFuture -> receiveMessageFromWorker
In addition: There were 35 warnings (use warnings() to see them)
Execution halted
