---Start Time: 2025-05-07 17:48:39.834367
Initialising Simcyp
wksz = D:\Users\james.craig\VBE\PP3\simcyp_vbe_output_14\PP3M 350mg.wksz
Initialised Simcyp Major Version: 24
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Workspace: D:\Users\james.craig\VBE\PP3\simcyp_vbe_output_14\PP3M 350mg.wksz

Substrate: Paliperidone Palmitate
Absorption model: First order
Distribution model: Minimal PBPK Model
Elimination: Enzyme kinetics
Route of administration: Custom
Dose 1 - 545.670000
Dose 2 - 545.670000
Dose 3 - 545.670000
Dose 4 - 545.670000
Dose 5 - 545.670000
Dose 6 - 545.670000
Dose scaling: mg
Dose Interval: 2016.000000
Dose Type: Multiple dose
Number of Doses: 6.000000

Substrate Primary Metabolite: Paliperidone 
Absorption model: First order
Distribution model: Full PBPK Model
Elimination: In vivo clearance

Population: Healthy Volunteers
Age Min: 18.000000
Age Max: 65.000000
Proportion of females: 0.500000

Study duration: 10920.000000
Population Type: Virtual population
Number Population: 2500
Number Group: 2500
Number Group Members: 1
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SetWorkspace Succeeded
[1] TRUE
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Setting parameter values
Setting parameter value for idLogNormalRadiusMean
/Workspace/Compounds/0/LAISuspensionFormulations/0/ParticleSolidState/idLogNormalRadiusMean=4.6357
Setting number of subjects to 10
Running simulation...
Simulation Complete
Importing concentration data from DB using:
CompoundID = Substrate
Start Time: 2025-05-07 17:48:39.834367
End Time: 2025-05-07 17:49:41.950105
Total Time: 1.035262 mins
Warning messages:
1: In load(TagsFile, temp_env <- new.env()) :
  strings not representable in native encoding will be translated to UTF-8
2: In load(TagsFile, envir = .GlobalEnv) :
  strings not representable in native encoding will be translated to UTF-8
3: package 'R.utils' was built under R version 4.4.3 
4: package 'xml2' was built under R version 4.4.3 
5: In load(TagsFile, temp_env <- new.env()) :
  strings not representable in native encoding will be translated to UTF-8
