Initialising Simcyp
wksz = D:\Users\james.craig\VBE\PP3\simcyp_vbe_output_15\PP3M 350mg.wksz
V24 is supported
Simcyp R package 24.0.18
making new Engine24 object
Looking for interface named Simcyp.Engine.24
Searching CLSID from registered name
Succeeded in QueryInterface
Simcyp System path set to: C:/Program Files/Simcyp Simulator V24/Screens/SystemFiles
Finished Initialisation
Back in R
Initialised Simcyp Major Version: 24
Initialisation ended
---------------------------------------------------------------------------
Workspace: D:\Users\james.craig\VBE\PP3\simcyp_vbe_output_15\PP3M 350mg.wksz

Substrate: Paliperidone Palmitate
Absorption model: First order
Distribution model: Minimal PBPK Model
Elimination: Enzyme kinetics
Route of administration: Custom
Dose 1 - 545.670000
Dose 2 - 545.670000
Dose 3 - 545.670000
Dose 4 - 545.670000
Dose 5 - 545.670000
Dose 6 - 545.670000
Dose scaling: mg
Dose Interval: 2016.000000
Dose Type: Multiple dose
Number of Doses: 6.000000

Substrate Primary Metabolite: Paliperidone 
Absorption model: First order
Distribution model: Full PBPK Model
Elimination: In vivo clearance

Population: Healthy Volunteers
Age Min: 18.000000
Age Max: 65.000000
Proportion of females: 0.500000

Study duration: 10920.000000
Population Type: Virtual population
Number Population: 2500
Number Group: 2500
Number Group Members: 1
---------------------------------------------------------------------------
SetWorkspace Succeeded
[1] TRUE
---------------------
Setting parameter values
Setting parameter value for idLogNormalRadiusMean
/Workspace/Compounds/0/LAISuspensionFormulations/0/ParticleSolidState/idLogNormalRadiusMean=4.6357
Setting number of subjects to 1
Running simulation...
Simulation started
wait for simulation
Simulation Complete
Out of WaitForSimulation
Detaching event handler from source

Simulation complete!
Importing concentration data from DB using:
CompoundID = Substrate
deleting pEngine
releasing pUnknown
Closing Handles
Cleared
Initialising Simcyp
wksz = D:\Users\james.craig\VBE\PP3\simcyp_vbe_output_15\PP3M 350mg.wksz
V24 is supported
Simcyp R package 24.0.18
making new Engine24 object
Looking for interface named Simcyp.Engine.24
Searching CLSID from registered name
Succeeded in QueryInterface
Simcyp System path set to: C:/Program Files/Simcyp Simulator V24/Screens/SystemFiles
Finished Initialisation
Back in R
Initialised Simcyp Major Version: 24
Initialisation ended
---------------------------------------------------------------------------
Workspace: D:\Users\james.craig\VBE\PP3\simcyp_vbe_output_15\PP3M 350mg.wksz

Substrate: Paliperidone Palmitate
Absorption model: First order
Distribution model: Minimal PBPK Model
Elimination: Enzyme kinetics
Route of administration: Custom
Dose 1 - 545.670000
Dose 2 - 545.670000
Dose 3 - 545.670000
Dose 4 - 545.670000
Dose 5 - 545.670000
Dose 6 - 545.670000
Dose scaling: mg
Dose Interval: 2016.000000
Dose Type: Multiple dose
Number of Doses: 6.000000

Substrate Primary Metabolite: Paliperidone 
Absorption model: First order
Distribution model: Full PBPK Model
Elimination: In vivo clearance

Population: Healthy Volunteers
Age Min: 18.000000
Age Max: 65.000000
Proportion of females: 0.500000

Study duration: 10920.000000
Population Type: Virtual population
Number Population: 2500
Number Group: 2500
Number Group Members: 1
---------------------------------------------------------------------------
SetWorkspace Succeeded
[1] TRUE
---------------------
Setting parameter values
Setting parameter value for idLogNormalRadiusMean
/Workspace/Compounds/0/LAISuspensionFormulations/0/ParticleSolidState/idLogNormalRadiusMean=4.6357
Setting number of subjects to 1
Running simulation...
Simulation started
wait for simulation
Simulation Complete
Out of WaitForSimulation
Detaching event handler from source

Simulation complete!
Importing concentration data from DB using:
CompoundID = Substrate
deleting pEngine
releasing pUnknown
Closing Handles
Cleared
Initialising Simcyp
wksz = D:\Users\james.craig\VBE\PP3\simcyp_vbe_output_15\PP3M 350mg.wksz
V24 is supported
Simcyp R package 24.0.18
making new Engine24 object
Looking for interface named Simcyp.Engine.24
Searching CLSID from registered name
Succeeded in QueryInterface
Simcyp System path set to: C:/Program Files/Simcyp Simulator V24/Screens/SystemFiles
Finished Initialisation
Back in R
Initialised Simcyp Major Version: 24
Initialisation ended
---------------------------------------------------------------------------
Workspace: D:\Users\james.craig\VBE\PP3\simcyp_vbe_output_15\PP3M 350mg.wksz

Substrate: Paliperidone Palmitate
Absorption model: First order
Distribution model: Minimal PBPK Model
Elimination: Enzyme kinetics
Route of administration: Custom
Dose 1 - 545.670000
Dose 2 - 545.670000
Dose 3 - 545.670000
Dose 4 - 545.670000
Dose 5 - 545.670000
Dose 6 - 545.670000
Dose scaling: mg
Dose Interval: 2016.000000
Dose Type: Multiple dose
Number of Doses: 6.000000

Substrate Primary Metabolite: Paliperidone 
Absorption model: First order
Distribution model: Full PBPK Model
Elimination: In vivo clearance

Population: Healthy Volunteers
Age Min: 18.000000
Age Max: 65.000000
Proportion of females: 0.500000

Study duration: 10920.000000
Population Type: Virtual population
Number Population: 2500
Number Group: 2500
Number Group Members: 1
---------------------------------------------------------------------------
SetWorkspace Succeeded
[1] TRUE
---------------------
Setting parameter values
Setting parameter value for idLogNormalRadiusMean
/Workspace/Compounds/0/LAISuspensionFormulations/0/ParticleSolidState/idLogNormalRadiusMean=4.6357
Setting number of subjects to 1
Running simulation...
Simulation started
wait for simulation
Simulation Complete
Out of WaitForSimulation
Detaching event handler from source

Simulation complete!
Importing concentration data from DB using:
CompoundID = Substrate
deleting pEngine
releasing pUnknown
Closing Handles
Cleared
Initialising Simcyp
wksz = D:\Users\james.craig\VBE\PP3\simcyp_vbe_output_15\PP3M 350mg.wksz
V24 is supported
Simcyp R package 24.0.18
making new Engine24 object
Looking for interface named Simcyp.Engine.24
Searching CLSID from registered name
Succeeded in QueryInterface
Simcyp System path set to: C:/Program Files/Simcyp Simulator V24/Screens/SystemFiles
Finished Initialisation
Back in R
Initialised Simcyp Major Version: 24
Initialisation ended
---------------------------------------------------------------------------
Workspace: D:\Users\james.craig\VBE\PP3\simcyp_vbe_output_15\PP3M 350mg.wksz

Substrate: Paliperidone Palmitate
Absorption model: First order
Distribution model: Minimal PBPK Model
Elimination: Enzyme kinetics
Route of administration: Custom
Dose 1 - 545.670000
Dose 2 - 545.670000
Dose 3 - 545.670000
Dose 4 - 545.670000
Dose 5 - 545.670000
Dose 6 - 545.670000
Dose scaling: mg
Dose Interval: 2016.000000
Dose Type: Multiple dose
Number of Doses: 6.000000

Substrate Primary Metabolite: Paliperidone 
Absorption model: First order
Distribution model: Full PBPK Model
Elimination: In vivo clearance

Population: Healthy Volunteers
Age Min: 18.000000
Age Max: 65.000000
Proportion of females: 0.500000

Study duration: 10920.000000
Population Type: Virtual population
Number Population: 2500
Number Group: 2500
Number Group Members: 1
---------------------------------------------------------------------------
SetWorkspace Succeeded
[1] TRUE
---------------------
Setting parameter values
Setting parameter value for idLogNormalRadiusMean
/Workspace/Compounds/0/LAISuspensionFormulations/0/ParticleSolidState/idLogNormalRadiusMean=4.6357
Setting number of subjects to 1
Running simulation...
Simulation started
wait for simulation
Simulation Complete
Out of WaitForSimulation
Detaching event handler from source

Simulation complete!
Importing concentration data from DB using:
CompoundID = Substrate
deleting pEngine
releasing pUnknown
Closing Handles
Cleared
Initialising Simcyp
wksz = D:\Users\james.craig\VBE\PP3\simcyp_vbe_output_15\PP3M 350mg.wksz
V24 is supported
Simcyp R package 24.0.18
making new Engine24 object
Looking for interface named Simcyp.Engine.24
Searching CLSID from registered name
Succeeded in QueryInterface
Simcyp System path set to: C:/Program Files/Simcyp Simulator V24/Screens/SystemFiles
Finished Initialisation
Back in R
Initialised Simcyp Major Version: 24
Initialisation ended
---------------------------------------------------------------------------
Workspace: D:\Users\james.craig\VBE\PP3\simcyp_vbe_output_15\PP3M 350mg.wksz

Substrate: Paliperidone Palmitate
Absorption model: First order
Distribution model: Minimal PBPK Model
Elimination: Enzyme kinetics
Route of administration: Custom
Dose 1 - 545.670000
Dose 2 - 545.670000
Dose 3 - 545.670000
Dose 4 - 545.670000
Dose 5 - 545.670000
Dose 6 - 545.670000
Dose scaling: mg
Dose Interval: 2016.000000
Dose Type: Multiple dose
Number of Doses: 6.000000

Substrate Primary Metabolite: Paliperidone 
Absorption model: First order
Distribution model: Full PBPK Model
Elimination: In vivo clearance

Population: Healthy Volunteers
Age Min: 18.000000
Age Max: 65.000000
Proportion of females: 0.500000

Study duration: 10920.000000
Population Type: Virtual population
Number Population: 2500
Number Group: 2500
Number Group Members: 1
---------------------------------------------------------------------------
SetWorkspace Succeeded
[1] TRUE
---------------------
Setting parameter values
Setting parameter value for idLogNormalRadiusMean
/Workspace/Compounds/0/LAISuspensionFormulations/0/ParticleSolidState/idLogNormalRadiusMean=4.6357
Setting number of subjects to 1
Running simulation...
Simulation started
wait for simulation
Simulation Complete
Out of WaitForSimulation
Detaching event handler from source

Simulation complete!
Importing concentration data from DB using:
CompoundID = Substrate
deleting pEngine
releasing pUnknown
Closing Handles
Cleared
Initialising Simcyp
wksz = D:\Users\james.craig\VBE\PP3\simcyp_vbe_output_15\PP3M 350mg.wksz
V24 is supported
Simcyp R package 24.0.18
making new Engine24 object
Looking for interface named Simcyp.Engine.24
Searching CLSID from registered name
Succeeded in QueryInterface
Simcyp System path set to: C:/Program Files/Simcyp Simulator V24/Screens/SystemFiles
Finished Initialisation
Back in R
Initialised Simcyp Major Version: 24
Initialisation ended
---------------------------------------------------------------------------
Workspace: D:\Users\james.craig\VBE\PP3\simcyp_vbe_output_15\PP3M 350mg.wksz

Substrate: Paliperidone Palmitate
Absorption model: First order
Distribution model: Minimal PBPK Model
Elimination: Enzyme kinetics
Route of administration: Custom
Dose 1 - 545.670000
Dose 2 - 545.670000
Dose 3 - 545.670000
Dose 4 - 545.670000
Dose 5 - 545.670000
Dose 6 - 545.670000
Dose scaling: mg
Dose Interval: 2016.000000
Dose Type: Multiple dose
Number of Doses: 6.000000

Substrate Primary Metabolite: Paliperidone 
Absorption model: First order
Distribution model: Full PBPK Model
Elimination: In vivo clearance

Population: Healthy Volunteers
Age Min: 18.000000
Age Max: 65.000000
Proportion of females: 0.500000

Study duration: 10920.000000
Population Type: Virtual population
Number Population: 2500
Number Group: 2500
Number Group Members: 1
---------------------------------------------------------------------------
SetWorkspace Succeeded
[1] TRUE
---------------------
Setting parameter values
Setting parameter value for idLogNormalRadiusMean
/Workspace/Compounds/0/LAISuspensionFormulations/0/ParticleSolidState/idLogNormalRadiusMean=4.6357
Setting number of subjects to 1
Running simulation...
Simulation started
wait for simulation
Simulation Complete
Out of WaitForSimulation
Detaching event handler from source

Simulation complete!
Importing concentration data from DB using:
CompoundID = Substrate
deleting pEngine
releasing pUnknown
Closing Handles
Cleared
Initialising Simcyp
wksz = D:\Users\james.craig\VBE\PP3\simcyp_vbe_output_15\PP3M 350mg.wksz
V24 is supported
Simcyp R package 24.0.18
making new Engine24 object
Looking for interface named Simcyp.Engine.24
Searching CLSID from registered name
Succeeded in QueryInterface
Simcyp System path set to: C:/Program Files/Simcyp Simulator V24/Screens/SystemFiles
Finished Initialisation
Back in R
Initialised Simcyp Major Version: 24
Initialisation ended
---------------------------------------------------------------------------
Workspace: D:\Users\james.craig\VBE\PP3\simcyp_vbe_output_15\PP3M 350mg.wksz

Substrate: Paliperidone Palmitate
Absorption model: First order
Distribution model: Minimal PBPK Model
Elimination: Enzyme kinetics
Route of administration: Custom
Dose 1 - 545.670000
Dose 2 - 545.670000
Dose 3 - 545.670000
Dose 4 - 545.670000
Dose 5 - 545.670000
Dose 6 - 545.670000
Dose scaling: mg
Dose Interval: 2016.000000
Dose Type: Multiple dose
Number of Doses: 6.000000

Substrate Primary Metabolite: Paliperidone 
Absorption model: First order
Distribution model: Full PBPK Model
Elimination: In vivo clearance

Population: Healthy Volunteers
Age Min: 18.000000
Age Max: 65.000000
Proportion of females: 0.500000

Study duration: 10920.000000
Population Type: Virtual population
Number Population: 2500
Number Group: 2500
Number Group Members: 1
---------------------------------------------------------------------------
SetWorkspace Succeeded
[1] TRUE
---------------------
Setting parameter values
Setting parameter value for idLogNormalRadiusMean
/Workspace/Compounds/0/LAISuspensionFormulations/0/ParticleSolidState/idLogNormalRadiusMean=4.6357
Setting number of subjects to 1
Running simulation...
Simulation started
wait for simulation
Simulation Complete
Out of WaitForSimulation
Detaching event handler from source

Simulation complete!
Importing concentration data from DB using:
CompoundID = Substrate
deleting pEngine
releasing pUnknown
Closing Handles
Cleared
Initialising Simcyp
wksz = D:\Users\james.craig\VBE\PP3\simcyp_vbe_output_15\PP3M 350mg.wksz
V24 is supported
Simcyp R package 24.0.18
making new Engine24 object
Looking for interface named Simcyp.Engine.24
Searching CLSID from registered name
Succeeded in QueryInterface
Simcyp System path set to: C:/Program Files/Simcyp Simulator V24/Screens/SystemFiles
Finished Initialisation
Back in R
Initialised Simcyp Major Version: 24
Initialisation ended
---------------------------------------------------------------------------
Workspace: D:\Users\james.craig\VBE\PP3\simcyp_vbe_output_15\PP3M 350mg.wksz

Substrate: Paliperidone Palmitate
Absorption model: First order
Distribution model: Minimal PBPK Model
Elimination: Enzyme kinetics
Route of administration: Custom
Dose 1 - 545.670000
Dose 2 - 545.670000
Dose 3 - 545.670000
Dose 4 - 545.670000
Dose 5 - 545.670000
Dose 6 - 545.670000
Dose scaling: mg
Dose Interval: 2016.000000
Dose Type: Multiple dose
Number of Doses: 6.000000

Substrate Primary Metabolite: Paliperidone 
Absorption model: First order
Distribution model: Full PBPK Model
Elimination: In vivo clearance

Population: Healthy Volunteers
Age Min: 18.000000
Age Max: 65.000000
Proportion of females: 0.500000

Study duration: 10920.000000
Population Type: Virtual population
Number Population: 2500
Number Group: 2500
Number Group Members: 1
---------------------------------------------------------------------------
SetWorkspace Succeeded
[1] TRUE
---------------------
Setting parameter values
Setting parameter value for idLogNormalRadiusMean
/Workspace/Compounds/0/LAISuspensionFormulations/0/ParticleSolidState/idLogNormalRadiusMean=4.6357
Setting number of subjects to 3
Running simulation...
Simulation started
wait for simulation
Simulation Complete
Out of WaitForSimulation
Detaching event handler from source

Simulation complete!
Importing concentration data from DB using:
CompoundID = Substrate
deleting pEngine
releasing pUnknown
Closing Handles
Cleared
There were 50 or more warnings (use warnings() to see the first 50)
Start Time: 2025-05-08 08:34:48.706956
End Time: 2025-05-08 08:35:48.001557
Total Time: 59.2946 secs
